A dithiacyclam-coordinated silver(i) polymer with anti-cancer stem cell activity

Johnson, A. and Iffland, L. and Singh, K. and Apfel, U.-P. and Suntharalingam, K.

Volume: 50 Pages: 5779-5783
DOI: 10.1039/d1dt01155c
Published: 2021

A cancer stem cell (CSC) active, solution stable, silver(i) polymeric complex bearing a dithiacyclam ligand is reported. The complex displays similar potency towards CSCs to salinomycin in monolayer and three-dimensional cultures. Mechanistic studies suggest CSC death results from cytosol entry, an increase in intracellular reactive oxygen species, and caspase-dependent apoptosis. © The Royal Society of Chemistry 2021.

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