Publications

Rhodium-Catalyzed ortho-Arylation of (Hetero)aromatic Acids

Weber, P. and Rank, C.K. and Yalcinkaya, E. and Dyga, M. and van Lingen, T. and Schmid, R. and Patureau, F.W. and Gooßen, L.J.

ADVANCED SYNTHESIS AND CATALYSIS
Volume: 361 Pages: 3925-3929
DOI: 10.1002/adsc.201900596
Published: 2019

Abstract
Rhodium acetate effectively promotes the carboxylate-directed ortho-arylation of (hetero)aromatic carboxylates with aryl bromides. The main advantage of this phosphine-free, redox-neutral method arises from its efficiency in assembling biologically meaningful electron-rich arylpyridines, which are problematic substrates in known C−H arylations using Pd, Ru, and Ir catalysts. (Figure presented.). © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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