Publications

Metal-free trifluoromethylthiolation of arenediazonium salts with Me4NSCF3

Bertoli, G. and Exner, B. and Evers, M.V. and Tschulik, K. and Gooßen, L.J.

JOURNAL OF FLUORINE CHEMISTRY
Volume: 210 Pages: 132-136
DOI: 10.1016/j.jfluchem.2018.03.011
Published: 2018

Abstract
A metal-free entry to the pharmaceutically meaningful substrate class of trifluoromethyl thioethers has been developed starting from widely available arenediazonium salts and commercially available Me4N+SCF3 −. This reaction proceeds within one hour at 0 °C and is applicable to a wide range of functionalized substrates. © 2018 Elsevier B.V.

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