Publications

Electrochemical C-H Cyanation of Electron-Rich (Hetero)Arenes

Hayrapetyan, D. and Rit, R.K. and Kratz, M. and Tschulik, K. and Gooßen, L.J.

CHEMISTRY - A EUROPEAN JOURNAL
Volume: Pages:
DOI: 10.1002/chem.201802247
Published: 2018

Abstract
A straightforward method for the electrochemical C-H cyanation of arenes and heteroarenes that proceeds at room temperature in MeOH, with NaCN as the reagent in a simple, open, undivided electrochemical cell is reported. The platinum electrodes are passivated by adsorbed cyanide, which allows conversion of an exceptionally broad range of electron-rich substrates all the way down to dialkyl arenes. The cyanide electrolyte can be replenished with HCN, opening opportunities for salt-free industrial C-H cyanation. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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